Exceptional mixed-use investment opportunity on Main Street directly across from Sisters Hospital. The first floor features a former medical office with reception area, multiple exam rooms, clerical space, and an additional rear office, making it well suited for medical, professional, or office use.
The second floor offers two fully remodeled apartments, including one 2-bedroom, 1-bath unit and one 2-bedroom, 2-bath unit. Both units feature updated flooring, modern finishes, updated mechanicals, and city views, providing immediate strong rental appeal. The third floor offers an unfinished attic with excellent storage or bonus space.
Additional features include a private driveway, detached 4-car garage, attached one car garage, and frontage on a public transit route. The highly visible location across from Sisters Hospital provides excellent exposure for a commercial user while the residential units create immediate income potential. Ideal for an owner-occupant or investor seeking a property with both cash flow and long-term upside.
The second floor offers two fully remodeled apartments, including one 2-bedroom, 1-bath unit and one 2-bedroom, 2-bath unit. Both units feature updated flooring, modern finishes, updated mechanicals, and city views, providing immediate strong rental appeal. The third floor offers an unfinished attic with excellent storage or bonus space.
Additional features include a private driveway, detached 4-car garage, attached one car garage, and frontage on a public transit route. The highly visible location across from Sisters Hospital provides excellent exposure for a commercial user while the residential units create immediate income potential. Ideal for an owner-occupant or investor seeking a property with both cash flow and long-term upside.
Property Details
Price:
$499,777
MLS #:
B1703329
Status:
Active
Beds:
0
Baths:
0
Type:
Commercial
Subtype:
MixedUse
Subdivision:
North Buffalo
Neighborhood:
buffalocity140200
Listed Date:
Aug 3, 2026
Finished Sq Ft:
5,040
Total Sq Ft:
5,040
Lot Size:
6,125 sqft / 0.14 acres (approx)
Year Built:
1900
See this Listing
Schools
School District:
Buffalo
Interior
Flooring
Carpet, Hardwood, Linoleum, Varies, Vinyl
Heating
Other, See Remarks, Hot Water
Exterior
Lot Features
Rectangular, Rectangular Lot
Parking Spots
8
Parking Total
8
Roof
Asphalt
Stories
3
Financial
Taxes
$6,622
Map
Community
- Address2148 Main Street Buffalo NY
- CityBuffalo
- CountyErie
- Zip Code14214
Subdivisions in Buffalo
- 200 Delaware Condo
- 770 West Ferry Condo
- 800 West Ferry Condo
- Admirals Walk Condo
- Allentown
- Appollos Stevens
- Bailey Estate
- Bailey Estates
- Bailey-Lovejoy
- Berkshire Terrace
- Bird Farm
- Black Rock
- Bronson Park
- Bryant Parish Condo
- Buffal0 Crk Reservation
- Buffalo
- Buffalo Creek Reservation
- Buffalo Crk
- Buffalo Crk Indian Reserv
- Buffalo Crk Reservation
- Buffalo Stove Works Prop
- Carriage Lane Condo Bldg
- Central Park
- City Centre Condo
- City Of Buffalo
- City/Buffalo
- Cold Springs
- Colvin Estates
- Colvin Park
- Colvin Park New 04
- Delaware District
- Delaware Tower
- Delaware Tower Condo
- Delaware Tower Condos
- Downtown
- Drexel Add
- Drexel Sub
- East Side
- Ebenezer Lands
- Elmwood
- Elmwood Strip
- Estate/James H Metcalfe
- Executive Condo
- Ferry
- Ferry Lt
- Fillmore Leroy
- First Ward
- Fruit Belt
- Gore
- Gore Tr
- Hamlin Park
- Highland Park
- Historic Warehouse Condo
- Holland Company’s Surv
- Holland Land
- Holland Land Co
- Holland Land Companies Su
- Holland Land Company
- Holland Land Company ‘s S
- Holland Land Company Surv
- Holland Land Company’s Su
- Holland Land Companys
- Holland Land Companys Sur
- Holland Land Cos Curv
- HOLLAND LAND COS SURV
- Holland Land’s Company Su
- Holland Lands Company’s S
- Homes Tr
- Hospital Hill
- Humboldt Park
- James Sperry’s Surv
- Jones
- Jones Tr
- Kaisertown
- Kensington
- Kensington Park
- Land Company’s Surv
- Lands/The Richmond Avenue
- Lang Field Sub Map #2
- Lee & Mcphersons Sub
- Lower West Side
- Manns Plan
- Marina Park Condo B Bldg
- Masten Park
- New York State Reservatio
- Niagara
- North Buffalo
- Parish
- Parish Tr
- Parkside
- Pasquale Condo
- Polonia
- Rivermist Dev Ph 1
- Riverside
- Schiller Park
- South Buffalo
- South Vlg/Black Rock
- St Marys Square Condo
- Steven’s Surv
- Stevens Surv
- University District
- University Heights
- University Park Sub
- Waterfront Village Pt I
- Waterfront Village Pt Ii
- West Side
- Willert Park
- Willert Park Village Ph 1
Market Summary
Current real estate data for Commercial in Buffalo as of Aug 27, 2026
131
Commercial Listed
154
Avg DOM
81
Avg $ / SqFt
$507,075
Avg List Price
Property Summary
- 2148 Main Street Buffalo NY is a Commercial for sale in Buffalo, NY, 14214. It is listed for $499,777
Similar Listings Nearby
Courtesy of Howard Hanna WNY Inc.. Disclaimer: All data relating to real estate for sale on this page comes from the Broker Reciprocity (BR) of the New York State Alliance of MLSs. Detailed information about real estate listings held by brokerage firms other than Michael Paduano include the name of the listing broker. Neither the listing company nor Michael Paduano shall be responsible for any typographical errors, misinformation, misprints and shall be held totally harmless. The Broker providing this data believes it to be correct, but advises interested parties to confirm any item before relying on it in a purchase decision. Copyright 2026. New York State Alliance of MLSs. All rights reserved. 2148 Main Street
Buffalo, NY

