Exceptional opportunity to own a substantial mixed-use brick building in the heart of the University District, just steps from the University at Buffalo and train station. 3125 Main is over 6,500 sq’, has been owned long-term and is now available as a turn-key medical or professional facility, w/ flexibility for multiple businesses or users. The layout allows for easy division into separate practices or businesses, multiple entrances and excellent flow. The first floor is currently configured as a fully operational medical office featuring a welcoming waiting room, 6 exam rooms, bathroom, and a large private office. North side includes three rooms and a bathroom. Central hallway offers 2 additional bathrooms. Two more first-floor rooms w/ sinks can serve either side or a separate business entirely. An additional 1,200 sq ft of unfinished space on the second floor provides significant expansion potential. The 2nd flr apartment offers 2–4 bedrooms, freshly updated w/ new paint and flooring. Ideal for owner occupancy or rental income. A walk-up attic could also be finished for even more usable square footage. Additional highlights: brick construction, asphalt roof (2018), parking for 10+, wheelchair ramp. Don’t miss your chance to own this move in ready property w/ income potential in a high demand location!
Property Details
Price:
$600,000
MLS #:
B1660976
Status:
Active
Beds:
0
Baths:
0
Type:
Commercial
Subtype:
Office
Subdivision:
University Heights
Neighborhood:
buffalocity140200
Listed Date:
Feb 4, 2026
Finished Sq Ft:
6,518
Total Sq Ft:
6,518
Lot Size:
9,138 sqft / 0.21 acres (approx)
Year Built:
1990
See this Listing
Schools
School District:
Buffalo
Interior
Cooling
Zoned, Central Air
Flooring
Carpet, Linoleum, Vinyl
Heating
Gas, Zoned, Baseboard
Exterior
Construction Materials
Brick
Parking Features
On Site, Surfaced
Parking Spots
10
Roof
Flat, Shingle
Financial
Taxes
$12,449
Map
Community
- Address3125 Main Street Buffalo NY
- CityBuffalo
- CountyErie
- Zip Code14214
Subdivisions in Buffalo
- 200 Delaware Condo
- 200 Delaware Residential
- 770 West Ferry Condo
- 800 West Ferry Condo
- 900 Delaware Condo
- Admirals Walk Condo
- Allentown
- Apollos Stevens Surv
- Appollo Stevens Surv
- Appollos Stevens Surv
- Bailey Estate 01
- Bailey Estates
- Bailey-Lovejoy
- Barker Square Condo
- Berkshire Terrace
- Bethune Lofts
- Bird Farm
- Black Rock
- Boulevard Land Co
- Bryant Parish Condo
- Buffalo
- Buffalo Crk Erservation
- Buffalo Crk Indian Reserv
- Buffalo Crk Resermation
- Buffalo Crk Reservation
- Buffalo Crk Sub
- Central Park
- City Centre Condo
- City/Buffalo
- Cold Springs
- Colvin Estates
- Colvin Park 01
- Colvin Park Map #4
- Colvin Park Sub Map #1
- Colvin Park Sub Map #2
- Congress Street
- Copeland Place
- Delaware District
- Delaware Tower
- Delaware Tower Condo
- Delaware Tower Condos
- Downtown
- East Side
- Elmwood
- Elmwood Strip
- Estate/James H Metcalfe
- Executive Condo
- Ferry
- Ferry Lt
- Fillmore Leroy
- First Ward
- Fruit Belt
- Garner
- Georgian Village Condo
- Gore
- Gore Tr
- Hamlin Park
- Highland Park
- Historic Warehouse Condo
- Historic Warehouse LLC
- Holland
- Holland Land
- Holland Land Co
- Holland Land Companies Su
- Holland Land Company
- Holland Land Company Surv
- Holland Land Company’s
- Holland Land Company’s Su
- Holland Land Companys
- Holland Land Companys Sub
- Holland Land Companys Sur
- Holland Land Compnay’s Su
- HOLLAND LAND COS SURV
- Holland Lands Company’s S
- Homes Tr
- Hospital Hill
- Humboldt Park
- Jones
- Jones Tr
- Jones Tract
- Judge’s Row
- Kaisertown
- Kensington
- Kensington Heights
- Kensington Park
- Lang Field Sub Map #2
- Late South Vlg/Black Rock
- Late Vlg/Black Rock
- Lee & Mcphersons Sub
- Lower West Side
- M Davey’s Surv
- Manns Plan
- Masten
- Masten Park
- Mile Reserve
- N3384/0001
- New York State Reservatio
- Niagara
- North Buffalo
- Ogden Gore Tr
- Parish
- Parish Tr
- Parish Tract
- Park Gardens Sub 1
- Park Gardens Sub 5
- Park Land Associations
- Park Lane Condo
- Park Meadow
- Park View Estates
- Parkside
- Pasquale Condo
- Polonia
- River View Land Co
- Rivermist Dev Ph 1
- Riverside
- Schiller Park
- Section 89 70
- South Buffalo
- South Park Sub
- South Village Black Road
- South Village Black Rock
- South Village/Black Rock
- South Vlg/Black Rock
- St Marys Square Condo
- Stevens Surv
- Symphony Circle Condo
- Tivoli Gardens Condo
- University District
- University Heights
- University Park Sub
- Vernon Triangle
- Waterfront Village Pt II
- Waterloo-Hubbell Sub
- West End Condo Bldg
- West Side
- Willert Park
- Woodside Land Co
Market Summary
Current real estate data for Commercial in Buffalo as of Feb 05, 2026
102
Commercial Listed
154
Avg DOM
124
Avg $ / SqFt
$609,512
Avg List Price
Property Summary
- 3125 Main Street Buffalo NY is a Commercial for sale in Buffalo, NY, 14214. It is listed for $600,000
Similar Listings Nearby
Courtesy of HUNT Real Estate Corporation. Disclaimer: All data relating to real estate for sale on this page comes from the Broker Reciprocity (BR) of the New York State Alliance of MLSs. Detailed information about real estate listings held by brokerage firms other than Michael Paduano include the name of the listing broker. Neither the listing company nor Michael Paduano shall be responsible for any typographical errors, misinformation, misprints and shall be held totally harmless. The Broker providing this data believes it to be correct, but advises interested parties to confirm any item before relying on it in a purchase decision. Copyright 2026. New York State Alliance of MLSs. All rights reserved. 3125 Main Street
Buffalo, NY

